Sequential testing epidemiology1/7/2023 The aim of this study is to provide a robust, multi-dimensional model analysis of the possible impact of syphilis on the German healthcare system in order to support healthcare decision-making by linking various health-related data sources. Claims data from statutory health insurance companies can close this information gap since they reflect real-life healthcare provisions better than clinical trials ( 13).Ĭombining different datasets into a model analysis is a helpful tool for developing recommendations and guidelines and for initiating effective public health measures ( 13). Nevertheless, these sources offer only limited information on some aspects, like treatment patterns and loss of productivity due to sick leave. However, blood donor data is a useful tool in providing information on the seroprevalence of syphilis in the population, making it suitable for monitoring the effects of public health programs ( 11, 12). Transmission via transfusion has not happened for over 15 years in Germany ( 10). Syphilis antibodies detected in blood donor samples must also be reported to the RKI ( 9). This offers a good insight into incident cases. Currently, most syphilis cases are diagnosed through serological testing ( 7) and, in Germany, all laboratories are obliged to anonymously report treponemal pallidum positive serological test results to the Robert Koch Institute (RKI) ( 8). Since the disease tends to manifest inconspicuously, an infection often remains undetected ( 6), resulting in an underassessment of infections. In addition, the clinical symptoms often indicate more than one possible differential diagnosis result ( 4, 5). While treatment of syphilis is assessable and cost effective, the diagnosis of syphilis is challenging because traditional tools like cultivation and gram staining are not available ( 3). neurosyphilis) and can even compromise pregnancy outcomes (including stillbirth and congenital syphilis) ( 2) thus it represents a serious health concern. Untreated or undetected infections can lead to severe health outcomes (f. The pathogen can be transmitted via transplacental transmission, sexual contact with infectious lesions, and blood transfusions ( 1). ![]() Syphilis is a systemic disease caused by the bacteria Treponema pallidum.
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